COMBINATION EFFECT ON HIV-INFECTION IN-VITRO OF SOLUBLE CD4 AND HIV-NEUTRALIZING ANTIBODIES

被引:6
作者
HANSEN, JES
SORENSEN, AM
OLOFSSON, S
OSINAGA, E
ROSETO, A
机构
[1] UNIV GOTEBORG,DEPT CLIN VIROL,GOTHENBURG,SWEDEN
[2] UNIV TECHNOL COMPIEGNE,DICA,CNRS,URA 523,COMPIEGNE,FRANCE
关键词
D O I
10.1007/BF01379116
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
In combination with HIV gp120 V3-loop antibody, two carbohydrate specific neutralizing antibodies (83D4 and 2G12) had a synergistic neutralizing effect on HIV infection. However, sCD4 and an antibody which blocks gp 120/CD4 binding (1B1) both displayed antagonism.
引用
收藏
页码:179 / 184
页数:6
相关论文
共 14 条
[1]   CARBOHYDRATE DETERMINANT NEUAC-GAL-BETA(1-4) OF N-LINKED GLYCANS MODULATES THE ANTIGENIC ACTIVITY OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 GLYCOPROTEIN GP120 [J].
BOLMSTEDT, A ;
OLOFSSON, S ;
SJOGRENJANSSON, E ;
JEANSSON, S ;
SJOBLOM, I ;
AKERBLOM, L ;
HANSEN, JES ;
HU, SL .
JOURNAL OF GENERAL VIROLOGY, 1992, 73 :3099-3105
[2]  
CHAMAT S, 1992, J IMMUNOL, V149, P649
[3]   QUANTITATIVE-ANALYSIS OF DOSE-EFFECT RELATIONSHIPS - THE COMBINED EFFECTS OF MULTIPLE-DRUGS OR ENZYME-INHIBITORS [J].
CHOU, TC ;
TALALAY, P .
ADVANCES IN ENZYME REGULATION, 1984, 22 :27-55
[4]   A CD4-DERIVED PEPTIDE CARRIER BLOCKS ACUTE HIV-1 INFECTION INVITRO AND BINDS TO GP120 IN THE PRESENCE OF WALTER-REED STAGE 1-6 HIV+ SERA [J].
GHETIE, V ;
WHEELER, T ;
SCOTT, D ;
UHR, JW ;
VITETTA, ES .
AIDS RESEARCH AND HUMAN RETROVIRUSES, 1992, 8 (11) :1945-1948
[5]   BROADLY NEUTRALIZING ANTIBODIES TARGETED TO MUCIN-TYPE CARBOHYDRATE EPITOPES OF HUMAN-IMMUNODEFICIENCY-VIRUS [J].
HANSEN, JES ;
NIELSEN, C ;
ARENDRUP, M ;
OLOFSSON, S ;
MATHIESEN, L ;
NIELSEN, JO ;
CLAUSEN, H .
JOURNAL OF VIROLOGY, 1991, 65 (12) :6461-6467
[6]   INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) INFECTION INVITRO BY ANTICARBOHYDRATE MONOCLONAL-ANTIBODIES - PERIPHERAL GLYCOSYLATION OF HIV ENVELOPE GLYCOPROTEIN-GP120 MAY BE A TARGET FOR VIRUS NEUTRALIZATION [J].
HANSEN, JES ;
CLAUSEN, H ;
NIELSEN, C ;
TEGLBJAERG, LS ;
HANSEN, LL ;
NIELSEN, CM ;
DABELSTEEN, E ;
MATHIESEN, L ;
HAKOMORI, SI ;
NIELSEN, JO .
JOURNAL OF VIROLOGY, 1990, 64 (06) :2833-2840
[7]   ANALYSIS OF SYNERGISM ANTAGONISM BETWEEN HIV-1 ANTIBODY-POSITIVE HUMAN SERA AND SOLUBLE CD4 IN BLOCKING HIV-1 BINDING AND INFECTIVITY [J].
KENNEDY, MS ;
ORLOFF, S ;
IBEGBU, CC ;
ODELL, CD ;
MADDON, PJ ;
MCDOUGAL, JS .
AIDS RESEARCH AND HUMAN RETROVIRUSES, 1991, 7 (12) :975-981
[8]  
MOORE JP, 1993, VIRAL FUSION MECH, P233
[9]  
OSINAGA E, 1993, IN PRESS J TUMOR MAR
[10]   PURIFICATION AND CHARACTERIZATION OF A BREAST-CANCER-ASSOCIATED GLYCOPROTEIN NOT EXPRESSED IN NORMAL BREAST AND IDENTIFIED BY MONOCLONAL ANTIBODY-83D4 [J].
PANCINO, G ;
OSINAGA, E ;
CHARPIN, C ;
MISTRO, D ;
BARQUE, JP ;
ROSETO, A .
BRITISH JOURNAL OF CANCER, 1991, 63 (03) :390-398