EPSTEIN-BARR-VIRUS INFECTIONS - BIOLOGY, PATHOGENESIS, AND MANAGEMENT

被引:307
作者
STRAUS, SE [1 ]
COHEN, JI [1 ]
TOSATO, G [1 ]
MEIER, J [1 ]
机构
[1] US FDA, CTR BIOL EVALUAT & RES, IMMUNOL LAB, BETHESDA, MD 20014 USA
关键词
EPSTEIN-BARR VIRUS; B-LYMPHOCYTES; INFECTIOUS MONONUCLEOSIS; BURKITTS LYMPHOMA; LYMPHOPROLIFERATIVE DISORDERS;
D O I
10.7326/0003-4819-118-1-199301010-00009
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Epstein-Barr virus (EBV) encodes genes that ensure its persistence in human B lymphocytes. Some of the genes encourage B-cell proliferation; others are poised to evade or defeat immune recognition. Immune restraints on the virus, however, are typically so effective that most infections are never symptomatic. In contrast, acute infectious mononucleosis, a self-limited lymphoproliferative illness, is common in adolescents and young adults. Unbridled proliferative illnesses arise when cellular immunity is grossly defective. Treatment of EBV-associated syndromes is largely supportive. Antiviral drugs have no proven role except in patients with oral hairy leukoplakia. Vaccine development is technically feasible but is not considered a high priority for developed nations.
引用
收藏
页码:45 / 58
页数:14
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