EPSTEIN-BARR-VIRUS INFECTIONS - BIOLOGY, PATHOGENESIS, AND MANAGEMENT

被引：307

作者：

STRAUS, SE ^{[1
]}

COHEN, JI ^{[1
]}

TOSATO, G ^{[1
]}

MEIER, J ^{[1
]}

机构：

[1] US FDA, CTR BIOL EVALUAT & RES, IMMUNOL LAB, BETHESDA, MD 20014 USA

来源：

ANNALS OF INTERNAL MEDICINE | 1993年 / 118卷 / 01期

关键词：

EPSTEIN-BARR VIRUS; B-LYMPHOCYTES; INFECTIOUS MONONUCLEOSIS; BURKITTS LYMPHOMA; LYMPHOPROLIFERATIVE DISORDERS;

D O I：

10.7326/0003-4819-118-1-199301010-00009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Epstein-Barr virus (EBV) encodes genes that ensure its persistence in human B lymphocytes. Some of the genes encourage B-cell proliferation; others are poised to evade or defeat immune recognition. Immune restraints on the virus, however, are typically so effective that most infections are never symptomatic. In contrast, acute infectious mononucleosis, a self-limited lymphoproliferative illness, is common in adolescents and young adults. Unbridled proliferative illnesses arise when cellular immunity is grossly defective. Treatment of EBV-associated syndromes is largely supportive. Antiviral drugs have no proven role except in patients with oral hairy leukoplakia. Vaccine development is technically feasible but is not considered a high priority for developed nations.

引用

页码：45 / 58

页数：14

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