APLYSIA CREB2 REPRESSES LONG-TERM FACILITATION - RELIEF OF REPRESSION CONVERTS TRANSIENT FACILITATION INTO LONG-TERM FUNCTIONAL AND STRUCTURAL-CHANGE

被引：465

作者：

BARTSCH, D ^{[1
]}

GHIRARDI, M ^{[1
]}

SKEHEL, PA ^{[1
]}

KARL, KA ^{[1
]}

HERDER, SP ^{[1
]}

CHEN, M ^{[1
]}

BAILEY, CH ^{[1
]}

KANDEL, ER ^{[1
]}

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,COLL PHYSICIANS & SURGEONS,CTR NEUROBIOL & BEHAV,NEW YORK,NY 10032

来源：

CELL | 1995年 / 83卷 / 06期

关键词：

D O I：

10.1016/0092-8674(95)90213-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The switch from short- to long-term facilitation induced by behavioral sensitization in Aplysia involves CREB-like proteins, as well as the immediate-early gene ApC/EBP. Using the bZIP domain of ApC/EBP in a two-hybrid system, we have cloned ApCREB2, a transcription factor constitutively expressed in sensory neurons that resembles human CREB2 and mouse ATF4. ApCREB2 represses ApCREB-1-mediated transcription in F9 cells. Injection of anti-ApCREB2 antibodies into Aplysia sensory neurons causes a single pulse of serotonin (5-HT), which induces only short-term facilitation lasting minutes, to evoke facilitation lasting more than 1 day. This facilitation has the properties of long-term facilitation: it requires transcription and translation, induces the growth of new synaptic connections, and occludes further facilitation by five pulses of 5-HT.

引用

页码：979 / 992

页数：14

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