APPLICATION OF FED-BATCH CULTURE TO CITRIC-ACID PRODUCTION BY ASPERGILLUS-NIGER - THE EFFECTS OF DILUTION RATE AND DISSOLVED-OXYGEN TENSION

被引：33

作者：

DAWSON, MW

MADDOX, IS

BOAG, IF

BROOKS, JD

机构：

[1] MASSEY UNIV,DEPT PROD TECHNOL,PALMERSTON NORTH,NEW ZEALAND

[2] MASSEY UNIV,DEPT FOOD TECHNOL,PALMERSTON NORTH,NEW ZEALAND

来源：

BIOTECHNOLOGY AND BIOENGINEERING | 1988年 / 32卷 / 02期

关键词：

ACIDS; -; Organic; BIOREACTORS; Chemostats; FUNGI; SUGAR; Fermentation;

D O I：

10.1002/bit.260320212

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Studies in conventional batch culture confirmed that the maximum citric acid production rate occurred prior to exhaustion of the growth-limiting nutrient, i. e. , when the growth rate was nonzero. The effects of dilution rate and the culture dissolved oxygen tension (DOT) were studied in chemostat culture. Maximum citric acid yield and production rate were observed at low dilution rate (0. 017 h** minus **1) and high DOT value (90% of saturation). These findings were applied to a nitrogen-limited fed-batch culture, and allowed a productivity increase of 100% when compared with conventional batch culture.

引用

页码：220 / 226

页数：7

共 16 条

[1] DESIGN OF LABORATORY CONTINUOUS-CULTURE EQUIPMENT FOR ACCURATE GASEOUS METABOLISM MEASUREMENTS [J].