ANTICONVULSANT ACTIVITY OF DI-N-PROPYLACETATE AND BRAIN MONOAMINE METABOLISM IN THE RAT

被引：3

作者：

ABED, WT

机构：

[1] Faculty of Medicine, Jordan University of Science and Technology, Irbid

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1990年 / 17卷 / 01期

关键词：

di‐n‐propylacetate; gamma‐aminobutyric acid; monoamines; pentylenetetrazol; seizures;

D O I：

10.1111/j.1440-1681.1990.tb01259.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Sodium di‐n‐propylacetate (DPA) treatment induced significant increases in brain contents of gamma‐aminobutyric acid (GABA), 5‐hydroxyindoleacetic acid (5‐HIAA) and homovanillic acid (HVA). Furthermore, the threshold for pentylenetetrazol (PTZ) clonic convulsions was also increased in response to DPA administration. 2. Pretreatment with inhibitors of monoamine synthesis α‐methyl‐p‐tyrosine (AMPT) and p‐chlorophenylalanine (PCPA) did not alter the anticonvulsant activity of DPA, but when given alone, both AMPT and PCPA caused significant decreases in brain monoamine contents and PTZ threshold seizures. 3. Experiments using probenecid suggest that the increases in 5‐HIAA and HVA seen after DPA treatment could have resulted from inhibition of their active transport out of the brain. These data indicate that the anticonvulsant action of DPA is not dependent on changes in monoamine metabolism in the brain. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：11 / 16

页数：6

共 33 条

[31] BEHAVIORAL AND ELECTROGRAPHIC EFFECTS OF L-5-HYDROXYTRYPTOPHAN AND D,L-PARACHLOROPHENYL-ALANINE ON EPILEPTIC SENEGALESE BABOON (PAPIO-PAPIO) [J].