PROSTAGLANDIN AND THROMBOXANE BIOSYNTHESIS

被引：372

作者：

SMITH, WL ^{[1
]}

MARNETT, LJ ^{[1
]}

DEWITT, DL ^{[1
]}

机构：

[1] VANDERBILT UNIV, MED CTR,SCH MED,CTR MOLEC TOXICOL,DEPT BIOCHEM, AB HANCOCK JR MEM LAB CANC RES, NASHVILLE, TN 37232 USA

来源：

PHARMACOLOGY & THERAPEUTICS | 1991年 / 49卷 / 03期

关键词：

D O I：

10.1016/0163-7258(91)90054-P

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We describe the enzymological regulation of the formation of prostaglandin (PG) D2, PGE2, PGF2-alpha, 9-alpha, 11-beta-PGF2, PGI2 (prostacyclin), and thromboxane (Tx) A2 from arachidonic acid. We discuss the three major steps in prostanoid formation: (a) arachidonate mobilization from monophosphatidyl-inositol involving phospholipase C, diglyceride lipase, and monoglyceride lipase and from phosphatidyl-choline involving phospholipase A2; (b) formation of prostaglandin endoperoxides (PGG2 and PGH2) catalyzed by the cyclooxygenase and peroxidase activities of PGH synthase; and (c) synthesis of PGD2, PGE2, PGF2-alpha, 9-alpha, 11-beta-PGF2, PGI2, and TxA2 from PGH2. We also include information on the roles of aspirin and other nonsteroidal anti-inflammatory drugs, dexamethasone and other anti-inflammatory steroids, platelet-derived growth factor (PDGF), and interleukin-1 in prostaglandin metabolism.

引用

页码：153 / 179

页数：27

共 246 条

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