NUCLEOTIDE AND DEDUCED AMINO-ACID-SEQUENCES OF THE GLYCOPROTEIN GENE OF RABIES VIRUS-VACCINE STRAIN VNUKOVO-32 - BRIEF REPORT

被引：9

作者：

FODOR, I

GRABKO, VI

KHOZINSKI, VV

SELIMOV, MA

机构：

[1] RUSSIAN ACAD SCI,INST BIOCHEM & PHYSIOL MICROORGANISMS,MOLEC VIROL LAB,PUSHCHINO 142292,RUSSIA

[2] RUSSIAN ACAD MED SCI,INST POLIOMYELITIS & VIRAL ENCEPHALITIS,MOSCOW,RUSSIA

来源：

ARCHIVES OF VIROLOGY | 1994年 / 135卷 / 3-4期

关键词：

D O I：

10.1007/BF01310030

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The glycoprotein gene of the rabies virus vaccine strain Vnukovo-32 was sequenced and the deduced protein sequence was analyzed and compared with that of various laboratory and street strains. The amino acid sequence homologies of strain Vnukovo-32 were compared with fixed strains ERA, SAD B19, PV, HEP-Flury, CVS and two street strains, canine and CXX89-1, were 98.9% (6 replacements), 98.3% (9), 96.2% (20), 91.4% (45), 87.0% (68), 93.5% (34) and 91.4% (45), respectively. Sequence alignments of the proteins revealed that the most conserved region is the ectodomain, whereas the transmembrane and cytoplasmic domains showed significant divergence.

引用

页码：451 / 459

页数：9

共 32 条

[21] RABIES VIRULENCE - EFFECT ON PATHOGENICITY AND SEQUENCE CHARACTERIZATION OF RABIES VIRUS MUTATIONS AFFECTING ANTIGENIC SITE-III OF THE GLYCOPROTEIN [J].