THE CHEMOTHERAPY OF RODENT MALARIA .47. STUDIES ON PYRONARIDINE AND OTHER MANNICH BASE ANTIMALARIALS

被引：106

作者：

PETERS, W

ROBINSON, BL

机构：

[1] Department of Medical Parasitology, London School of Hygiene/, Tropical Medicine, St. Albans AL4 OXQ, Winches Farm

来源：

ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY | 1992年 / 86卷 / 05期

关键词：

D O I：

10.1080/00034983.1992.11812694

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The activities of Mannich base antimalarials, including pyronaridine, have been explored against drug-sensitive (Plasmodium berghei N) and chloroquine-resistant (Plasmodium yoelii NS) rodent malaria parasites in vivo. Lines of these parasites have been developed with resistance to pyronaridine, amodiaquine, or WR 228,258. The responses and patterns of cross-resistance of these lines to Mannich bases and other blood schizontocides are inconsistent. It is concluded that some Mannich bases may prove still to be of value in the treatment of chloroquine-resistant Plasmodium falciparum infection.

引用

页码：455 / 465

页数：11

共 16 条

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