APPLICATION OF REMOTE PHOTOCYCLIZATION WITH A PAIR SYSTEM OF PHTHALIMIDE AND METHYLTHIO GROUPS - A PHOTOCHEMICAL-SYNTHESIS OF CYCLIC PEPTIDE MODELS

被引：17

作者：

SATO, Y ^{[1
]}

NAKAI, H ^{[1
]}

WADA, M ^{[1
]}

MIZOGUCHI, T ^{[1
]}

HATANAKA, Y ^{[1
]}

KANAOKA, Y ^{[1
]}

机构：

[1] HOKKAIDO UNIV, FAC PHARMACEUT SCI, KITA KU, SAPPORO, HOKKAIDO 060, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 12期

关键词：

PHOTOCHEMISTRY; REGIOSELECTIVE REMOTE PHOTOCYCLIZATION; SULFIDE-CONTAINING PHTHALIMIDE; DONOR ACCEPTOR PAIR SYSTEM; MACROCYCLIC SYNTHESIS; CYCLIC PEPTIDE MODEL;

D O I：

10.1248/cpb.40.3174

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Application of regioselective remote photocyclization of a pair system consisting of a phthalimide group and a methylthio group to a homologous series of N-substituted phthalimides (4 and 5) possessing a terminal sulfide function in the amide side chain was investigated. On irradiation, medium to large membered cyclic peptide-like compunds (6, 7 and 9), up to a thirty-eight membered ring product (6f), were synthesized in moderate yields.

引用

页码：3174 / 3180

页数：7

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