ENZYMATIC RESOLUTIONS OF HETEROCYCLIC ALCOHOLS

被引：14

作者：

HONIG, H

SHI, NY

POLANZ, G

机构：

[1] Institute of Organic Chemistry, Graz University of Technology, A-8010, Graz

来源：

BIOCATALYSIS | 1994年 / 9卷 / 1-4期

关键词：

HETEROCYCLIC ALCOHOL; LIPASE; CANDIDA-RUGOSA; PSEUDOMONAS-CEPACIA; ENANTIOSELECTIVE HYDROLYSIS; ENANTIOSELECTIVE TRANSESTERIFICATION;

D O I：

10.3109/10242429408992107

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The butyrates and acetates of heterocyclic alcohols like 3 - hydroxy tetrahydrofuran and - pyran, 3- and 4 - chromanol as well as the corresponding sulfur heterocycles were hydrolyzed using lipase from Candida rugosa (CRL) and from Pseudomonas cepacia. (PCL). Poor to excellent enantioselectivities were obtained depending on the structure of the substrates. An electrostatic amendment to the steric substrate model for PCL is proposed.

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页码：61 / 69

页数：9

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