SERIAL PLASMA-CONCENTRATIONS OF COCAETHYLENE, COCAINE, AND ETHANOL IN TRAUMA VICTIMS

被引:48
作者
BAILEY, DN
机构
[1] Division of Laboratory Medicine, Department of Pathology, University of California Medical Center, San Diego, CA
关键词
D O I
10.1093/jat/17.2.79
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Cocaethylene (EC), cocaine (COC), and ethanol (ETOH) concentrations were measured in 46 serial plasma samples from 15 male trauma victims. In all but two patients EC was detected on admission to the hospital. In the remaining two, EC was not detected throughout hospitalization. However, these two patients had the lowest ETOH concentrations in the series (200 and 300 mg/L). Plasma concentrations ranged up to 128 µg/L for EC, up to 421 µg/L for COC, and up to 5, 100 mg/L for ETOH. Ratios of EC to COC concentration (EC/COC) were as high as 4.1. Concentrations of EC showed statistically significant correlation with those of COC (p < 0.01). The plasma half-life (T1/2) of EC was found to be longer than that reported for COC (1 h) and was estimated to be 3.5, 4.5, and 5.5 h in three patients. © 1993 Oxford University Press.
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页码:79 / 83
页数:5
相关论文
共 19 条
[1]   PLASMA COCAETHYLENE CONCENTRATIONS IN PATIENTS TREATED IN THE EMERGENCY ROOM OR TRAUMA UNIT [J].
BAILEY, DN .
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1993, 99 (02) :123-127
[2]   THE ROLE OF THE LABORATORY IN TREATMENT OF THE POISONED PATIENT - LABORATORY PERSPECTIVE [J].
BAILEY, DN .
JOURNAL OF ANALYTICAL TOXICOLOGY, 1983, 7 (03) :136-141
[3]  
BOYER CS, 1992, J PHARMACOL EXP THER, V260, P939
[4]   COLLECTION AND HANDLING OF CLINICAL BLOOD-SAMPLES TO ASSURE THE ACCURATE MEASUREMENT OF COCAINE CONCENTRATION [J].
BROGAN, WC ;
KEMP, PM ;
BOST, RO ;
GLAMANN, DB ;
LANGE, RA ;
HILLIS, LD .
JOURNAL OF ANALYTICAL TOXICOLOGY, 1992, 16 (03) :152-154
[5]   CONCURRENT AND SIMULTANEOUS USE OF ALCOHOL WITH COCAINE - RESULTS OF NATIONAL SURVEY [J].
GRANT, BF ;
HARFORD, TC .
DRUG AND ALCOHOL DEPENDENCE, 1990, 25 (01) :97-104
[6]   COCAETHYLENE - A UNIQUE COCAINE METABOLITE DISPLAYS HIGH-AFFINITY FOR THE DOPAMINE TRANSPORTER [J].
HEARN, WL ;
FLYNN, DD ;
HIME, GW ;
ROSE, S ;
COFINO, JC ;
MANTEROATIENZA, E ;
WETLI, CV ;
MASH, DC .
JOURNAL OF NEUROCHEMISTRY, 1991, 56 (02) :698-701
[7]   COCAETHYLENE IS MORE POTENT THAN COCAINE IN MEDIATING LETHALITY [J].
HEARN, WL ;
ROSE, S ;
WAGNER, J ;
CIARLEGLIO, A ;
MASH, DC .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1991, 39 (02) :531-533
[8]   ANALYSIS OF COCAINE AND COCAETHYLENE IN BLOOD AND TISSUES BY GC-NPD AND GC-ION TRAP MASS-SPECTROMETRY [J].
HIME, GW ;
HEARN, WL ;
ROSE, S ;
COFINO, J .
JOURNAL OF ANALYTICAL TOXICOLOGY, 1991, 15 (05) :241-245
[9]  
JATLOW P, 1990, CLIN CHEM, V36, P1436
[10]   COCAETHYLENE - A NEUROPHARMACOLOGICALLY ACTIVE METABOLITE ASSOCIATED WITH CONCURRENT COCAINE-ETHANOL INGESTION [J].
JATLOW, P ;
ELSWORTH, JD ;
BRADBERRY, CW ;
WINGER, G ;
TAYLOR, JR ;
RUSSELL, R ;
ROTH, RH .
LIFE SCIENCES, 1991, 48 (18) :1787-1794