CELLULAR-LOCALIZATION OF ANGIOTENSIN TYPE-1 RECEPTOR AND ANGIOTENSINOGEN MESSENGER-RNAS IN THE SUBFORNICAL ORGAN OF THE RAT-BRAIN

被引:46
作者
LIPPOLDT, A
BUNNEMANN, B
IWAI, N
METZGER, R
INAGAMI, T
FUXE, K
GANTEN, D
机构
[1] KAROLINSKA INST,DEPT HISTOL & NEUROBIOL,BOX 60400,S-10401 STOCKHOLM 60,SWEDEN
[2] MAX DELBRUCK CTR MOLEC MED,BERLIN,GERMANY
[3] VANDERBILT UNIV,MED CTR,SCH MED,NASHVILLE,TN 37232
[4] GERMAN INST HIGH BLOOD PRESSURE RES,HEIDELBERG,GERMANY
[5] DEPT PHARMACOL,HEIDELBERG,GERMANY
关键词
BRAIN; ANGIOTENSIN TYPE-1 RECEPTOR MESSENGER RNA; ANGIOTENSINOGEN MESSENGER RNA; GLIAL FIBRILLARY ACIDIC PROTEIN IMMUNOCYTOCHEMISTRY; INSITU HYBRIDIZATION; RAT;
D O I
10.1016/0304-3940(93)90524-O
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The cellular localization of angiotensin type 1 receptor (AT 1) and angiotensinogen mRNA expression in the subfornical organ (SFO) of the rat brain has been studied by means of non-radioactive in situ hybridization combined with immunocytochemistry for glial fibrillary acidic protein (GFAP) and Neutral red staining. The AT 1 receptor mRNA expression is shown to be within putative nerve cells without any association with the glial fibrillary acidic protein (GFAP)-immunoreactive (IR) cells. In contrast the angiotensinogen cRNA expression is associated predominantly with GFAP-IR cells. The results demonstrate that a neuronal AT 1 receptor mediates the actions of circulating angiotensin II on the SFO and that the angiotensinogen mRNA is predominantly expressed in the SFO astroglial cells.
引用
收藏
页码:153 / 158
页数:6
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