MOLECULAR CHAPERONES AND THE IMMUNE-RESPONSE

被引：43

作者：

YOUNG, D ^{[1
]}

ROMAN, E ^{[1
]}

MORENO, C ^{[1
]}

OBRIEN, R ^{[1
]}

BORN, W ^{[1
]}

机构：

[1] NATL JEWISH CTR IMMUNOL & RESP MED,DENVER,CO 80206

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES | 1993年 / 339卷 / 1289期

关键词：

D O I：

10.1098/rstb.1993.0035

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Molecular chaperones belonging to heat shock protein families have been identified as prominent antigens in thr immune response to a wide variety of infections. Recognition of such highly conserved antigens may contribute to protective immunity but, in some circumstances, may also have pathological autoimmune consequences. Recognition of chaperones may be an inherent feature of the immune system. Peptide mapping experiments revealed an overlap between hsp 70-binding sites and immunodominant regions of three protein antigens, consistent with a possible functional activity for molecular chaperones in the processing and presentation of peptides during class II-restricted T lymphocyte responses. A functional role for molecular chaperones in antigen processing may be a factor which contributes to their immunogenicity.

引用

页码：363 / 368

页数：6

共 47 条

[1] STRUCTURE OF THE HUMAN CLASS-I HISTOCOMPATIBILITY ANTIGEN, HLA-A2 [J].