STRUCTURAL ORGANIZATION AND EXPRESSION OF THE HUMAN PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE-C BETA-3 GENE

被引：10

作者：

MAZURUK, K ^{[1
]}

SCHOEN, TJ ^{[1
]}

CHADER, GJ ^{[1
]}

RODRIGUEZ, IR ^{[1
]}

机构：

[1] NEI,RETINAL CELL & MOLEC BIOL LAB,BETHESDA,MD 20892

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 212卷 / 01期

关键词：

D O I：

10.1006/bbrc.1995.1955

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have cloned and fully sequenced the phospholipase C beta-3 (PLC beta-3) gene. The gene spans approx. 17 kb and consists of 31 exons and 30 introns. Ah intron-exon junctions obey the GT/AG rule. The gene is highly expressed in several human tissues including retina, brain and kidney; PLC beta-3 mRNA is detected at a much lower level in liver. Because of its importance in signal transduction, its chromosomal localization and its high expression in CNS and other tissues, the PLC beta-3 gene is a candidate in several human genetic diseases which, with the present genomic sequence, can now be fully examined. (C) 1995 Academic Press, Inc.

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页码：190 / 195

页数：6

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