ENDOTHELIUM-DEPENDENT CONTRACTION IN INTRAPULMONARY ARTERIES - MEDIATION BY ENDOTHELIAL NK1 RECEPTORS AND TXA(2)

被引：30

作者：

SHIRAHASE, H ^{[1
]}

KANDA, M ^{[1
]}

KURAHASHI, K ^{[1
]}

NAKAMURA, S ^{[1
]}

USUI, H ^{[1
]}

SHIMIZU, Y ^{[1
]}

机构：

[1] TOKAI UNIV,SCH MED,DEPT COMMUNITY HLTH,KANAGAWA 25911,JAPAN

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1995年 / 115卷 / 07期

关键词：

SUBSTANCE P; INTRAPULMONARY ARTERY; ENDOTHELIUM-DEPENDENT CONTRACTION (EDC); NK1; RECEPTOR; THROMBOXANE A(2) (TXA(2)); NEUROKININ A; NEUROKININ B; NK2;

D O I：

10.1111/j.1476-5381.1995.tb15028.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 We have examined whether three natural tachykinins, substance P (SP), neurokinin A (NKA) and neurokinin B (NKB) induce an endothelium-dependent contraction (EDC) in the rabbit isolated intrapulmonary artery. 2 Removal of the endothelium almost abolished the contraction induced by SP (10(-8) M) while it did not attenuate the contraction induced by SP (10(-7) M), NKA (10(-9)-10(-7) M) or NKB (10(-8) and 10(-7) M). 3 The EDC induced by SP (10(-8) M) was abolished by M(1 antagonists (FK-888, CP-96345, CP-99994 and SR-140333) but not by an NK2 antagonist (SR-48968). 4 The EDC induced by SP was attenuated by cyclo-oxygenase inhibitors (aspirin and indomethacin), thromboxane A(2) (TXA(2)) synthetase inhibitors (OKY-046, KY-234 and KY-063) and a TXA(2) antagonist (S-1452). 5 The rank order of potency causing endothelium-independent contraction (EIC) was NKA > NKB > SP. The EIC induced by SP (10(-7) M) was attenuated by an NK2 antagonist but not by NK1 antagonists, cyclo-oxygenase inhibitors, TXA(2) synthetase inhibitors or a TXA(2) antagonist. 6 In conclusion, SP at 10(-8) M induces EDC via endothelial NK1 receptors and TXA(2) production, and SP at 10(-7) M induces EIC via NK2 receptors in the rabbit intrapulmonary artery.

引用

页码：1215 / 1220

页数：6