STRATEGIES FOR THE CHEMOENZYMATIC PREPARATION OF OPTICALLY-ACTIVE 1-ALKYN-3-OLS

被引：9

作者：

GLANZER, BI ^{[1
]}

KONIGSBERGER, K ^{[1
]}

BERGER, B ^{[1
]}

FABER, K ^{[1
]}

GRIENGL, H ^{[1
]}

机构：

[1] GRAZ UNIV TECHNOL, INST ORGAN CHEM, STREMAYRGASSE 16, A-8010 GRAZ, AUSTRIA

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 1990年 / 54卷 / 01期

基金：

奥地利科学基金会;

关键词：

1-alkyn-3-ols; enzymatic resolution; leukotrienes; lipase; yeast;

D O I：

10.1016/0009-3084(90)90058-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of (R)- and (S)-1-alkyn-3-ols, chiral building units for the synthesis of leukotrienes and pheromones, were prepared via enantioselective hydrolysis of their racemic esters. While the majority of biocatalysts employed (lipases, fermenting or freeze-dried microorganisms) failed in discriminating between enantiomers, lyophilized cells of baker's yeast (Saccharomyces cerevisiae Hansen) gave (S)-1-alkyn-3-ols and their corresponding (R)-esters with > 90% e.e. © 1990.

引用

页码：43 / 48

页数：6

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