RELEASE OF NIFEDIPINE THROUGH CROSS-LINKED CHITOSAN MEMBRANES

被引：40

作者：

THACHARODI, D ^{[1
]}

RAO, KP ^{[1
]}

机构：

[1] CENT LEATHER RES INST,DIV BIOMAT,MADRAS 600020,TAMIL NADU,INDIA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1993年 / 96卷 / 1-3期

关键词：

CHITOSAN; NIFEDIPINE; CROSS-LINKING; PERMEABILITY;

D O I：

10.1016/0378-5173(93)90209-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The permeability characteristics of a chitosan membrane using the anti-hypertensive drug nifedipine have been investigated. Chitosan membranes were crosslinked with different concentrations of glutaraldehyde and the effect of crosslinking on the permeability characteristics was studied. Permeation studies were carried out in static glass diffusion cells. With increasing degree of crosslinking a definite decrease in the diffusion coefficient, equilibrium swelling, partition coefficient and permeability coefficient was observed. These data supported the involvement of both pore and partition mechanisms in the transport of a hydrophobic drug such as nifedipine through chitosan/crosslinked chitosan membranes. It has been shown that by altering the permeability of chitosan membranes by different degrees of crosslinking the release of bioactive agents could be programmed.

引用

页码：33 / 39

页数：7

共 17 条

[1] ACTION OF LYSOZYME ON PARTIALLY DEACETYLATED CHITIN [J].

AMANO, KI ;

ITO, E .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1978, 85 (01) :97-104

[2]

HIRANO S, 1990, PROGRESS IN BIOMEDICAL POLYMERS, P283

[3]

Hirano S., 1987, ADV BIOMEDICAL POLYM, P285, DOI [10.1007/978-1-4613-1829-3_26, DOI 10.1007/978-1-4613-1829-3_26]

[4]

KRAJEWSKA B, 1990, J CHEM TECHNOL BIOT, V48, P337

[5] PERMEABILITY PROPERTIES OF GLYCOL CHITOSAN MEMBRANE MODIFIED WITH THIOL-GROUPS [J].

KUBOTA, N ;

OHGA, K ;

MORIGUCHI, M .

JOURNAL OF APPLIED POLYMER SCIENCE, 1991, 42 (02) :495-501

[6] INVITRO EVALUATION OF MUCOADHESIVE PROPERTIES OF CHITOSAN AND SOME OTHER NATURAL POLYMERS [J].

LEHR, CM ;

BOUWSTRA, JA ;

SCHACHT, EH ;

JUNGINGER, HE .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1992, 78 (01) :43-48

[7]

MIYAZAKI S, 1988, CHEM PHARM BULL, V36, P4033

[8]

MIYAZAKI S, 1990, ACTA PHARM NORDICA, V2, P401

[9] BIOLOGICAL-ACTIVITY OF CHITOSAN - ULTRASTRUCTURAL-STUDY [J].

MUZZARELLI, R ;

BALDASSARRE, V ;

CONTI, F ;

FERRARA, P ;

BIAGINI, G ;

GAZZANELLI, G ;

VASI, V .

BIOMATERIALS, 1988, 9 (03) :247-252

[10] PERMEABILITY OF VITAMIN-B12 IN CHITOSAN MEMBRANES - EFFECT OF CROSS-LINKING AND BLENDING WITH POLY(VINYL ALCOHOL) ON PERMEABILITY [J].

NAKATSUKA, S ;

ANDRADY, AL .

JOURNAL OF APPLIED POLYMER SCIENCE, 1992, 44 (01) :17-28

← 1 2 →