RILUZOLE PREVENTS ANOXIC INJURY IN CULTURED CEREBELLAR GRANULE NEURONS

被引：20

作者：

DESSI, F ^{[1
]}

BENARI, Y ^{[1
]}

CHARRIAUTMARLANGUE, C ^{[1
]}

机构：

[1] INSERM,U29,123 BD PORT ROYAL,F-75674 PARIS,FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 250卷 / 02期

关键词：

ANOXIA; GRANULE CELL CULTURE; GLUTAMATE RELEASE;

D O I：

10.1016/0014-2999(93)90398-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Glutamate release has been reported to be involved in the neuronal death following ischemic or anoxic injury. Riluzole (2-amino-6-trifluoromethoxy-benzothiazole) is a putative inhibitor of glutamate release. We investigated the effect of this drug on anoxic injury in vitro. Cerebellar granule cells grown in culture were exposed to an anoxic atmosphere for 16-20 h. Riluzole (100 muM) was found to prevent the degeneration of these neurons induced by anoxia.

引用

页码：325 / 328

页数：4

共 11 条

[1] POTASSIUM CHANNEL ACTIVATORS ABOLISH EXCITOTOXICITY IN CULTURED HIPPOCAMPAL PYRAMIDAL NEURONS
ABELE, AE
MILLER, RJ
[J]. NEUROSCIENCE LETTERS, 1990, 115 (2-3) : 195 - 200
[2] ACTIVATORS OF ATP-SENSITIVE K+ CHANNELS REDUCE ANOXIC DEPOLARIZATION IN CA3 HIPPOCAMPAL-NEURONS
BENARI, Y
KRNJEVIC, K
CREPEL, V
[J]. NEUROSCIENCE, 1990, 37 (01) : 55 - 60
[3] RILUZOLE INHIBITS THE RELEASE OF GLUTAMATE IN THE CAUDATE-NUCLEUS OF THE CAT INVIVO
CHERAMY, A
BARBEITO, L
GODEHEU, G
GLOWINSKI, J
[J]. NEUROSCIENCE LETTERS, 1992, 147 (02) : 209 - 212
[4] THE ROLE OF GLUTAMATE NEUROTOXICITY IN HYPOXIC-ISCHEMIC NEURONAL DEATH
CHOI, DW
ROTHMAN, SM
[J]. ANNUAL REVIEW OF NEUROSCIENCE, 1990, 13 : 171 - 182
[5] ANISOMYCIN AND CYCLOHEXIMIDE PROTECT CEREBELLAR NEURONS IN CULTURE FROM ANOXIA
DESSI, F
CHARRIAUTMARLANGUE, C
BENARI, Y
[J]. BRAIN RESEARCH, 1992, 581 (02) : 323 - 326
[6] PERTUSSIS TOXIN PRETREATMENT ABOLISHES THE INHIBITORY EFFECT OF RILUZOLE AND CARBACHOL ON D-[H-3]ASPARTATE RELEASE FROM CULTURED CEREBELLAR GRANULE CELLS
DOBLE, A
HUBERT, JP
BLANCHARD, JC
[J]. NEUROSCIENCE LETTERS, 1992, 140 (02) : 251 - 254
[7] IBOTENIC ACID STIMULATES D-[H-3]ASPARTATE RELEASE FROM CULTURED CEREBELLAR GRANULE CELLS
HUBERT, JP
DOBLE, A
[J]. NEUROSCIENCE LETTERS, 1989, 96 (03) : 345 - 350
[8] MALGOURIS C, 1989, J NEUROSCI, V9, P3720
[9] OXYGEN OR GLUCOSE DEPRIVATION-INDUCED NEURONAL INJURY IN CORTICAL CELL-CULTURES IS REDUCED BY TETANUS TOXIN
MONYER, H
GIFFARD, RG
HARTLEY, DM
DUGAN, LL
GOLDBERG, MP
CHOI, DW
[J]. NEURON, 1992, 8 (05) : 967 - 973
[10] NEUROPROTECTIVE ACTIONS OF RILUZOLE IN RODENT MODELS OF GLOBAL AND FOCAL CEREBRAL-ISCHEMIA
PRATT, J
RATAUD, J
BARDOT, F
ROUX, M
BLANCHARD, JC
LADURON, PM
STUTZMANN, JM
[J]. NEUROSCIENCE LETTERS, 1992, 140 (02) : 225 - 230

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