RILUZOLE PREVENTS ANOXIC INJURY IN CULTURED CEREBELLAR GRANULE NEURONS

被引：20

作者：

DESSI, F ^{[1
]}

BENARI, Y ^{[1
]}

CHARRIAUTMARLANGUE, C ^{[1
]}

机构：

[1] INSERM,U29,123 BD PORT ROYAL,F-75674 PARIS,FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 250卷 / 02期

关键词：

ANOXIA; GRANULE CELL CULTURE; GLUTAMATE RELEASE;

D O I：

10.1016/0014-2999(93)90398-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Glutamate release has been reported to be involved in the neuronal death following ischemic or anoxic injury. Riluzole (2-amino-6-trifluoromethoxy-benzothiazole) is a putative inhibitor of glutamate release. We investigated the effect of this drug on anoxic injury in vitro. Cerebellar granule cells grown in culture were exposed to an anoxic atmosphere for 16-20 h. Riluzole (100 muM) was found to prevent the degeneration of these neurons induced by anoxia.

引用

页码：325 / 328

页数：4