H1-DEGREES AND H3.3B MESSENGER-RNA LEVELS IN DEVELOPING RAT-BRAIN

被引：32

作者：

CASTIGLIA, D ^{[1
]}

CESTELLI, A ^{[1
]}

SCATURRO, M ^{[1
]}

NASTASI, T ^{[1
]}

DILIEGRO, I ^{[1
]}

机构：

[1] DIPARTIMENTO BIOL CELLULARE & SVILUPPO ALBERTO MO,I-90123 PALERMO,ITALY

来源：

NEUROCHEMICAL RESEARCH | 1994年 / 19卷 / 12期

关键词：

HISTONE H1-DEGREES; HISTONES H3.3; RAT BRAIN DEVELOPMENT; CHROMATIN;

D O I：

10.1007/BF00969002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two overlapping rat cDNAs, covering a continuous region of 1107 base pairs, have been isolated and sequenced. The clones contain identical open reading frames, encoding a 136 amino acid long polypeptide which exhibits 100% identity to other mammalian H3.3 histone variants. We show that the inserts derive, in particular, from the H3.3B gene. We used these inserts and an insert from an H1 degrees encoding clone, previously described (6), as probes to study the accumulation of mRNAs encoding the corresponding histone replacement variants (namely; H1 degrees and H3.3) during rat brain development. We found that the concentration of both H1 degrees and H3.3B mRNAs decreases from the embryonal day 18 (E18) to the postnatal day 10 (P10), with inverse correlation to protein accumulation.

引用

页码：1531 / 1537

页数：7

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