INCREASED HISTONE H1-DEGREES EXPRESSION IN DIFFERENTIATING MOUSE ERYTHROLEUKEMIA-CELLS IS RELATED TO DECREASED CELL-PROLIFERATION

被引：12

作者：

BOIX, J ^{[1
]}

CARRILLO, AR ^{[1
]}

机构：

[1] UNIV HOTEL DIEU QUEBEC,CTR LAVAL,SCH MED & CANC RES,DEPT BIOCHEM,11 COTE PALAIS,QUEBEC CITY G1R 2J6,QUEBEC,CANADA

来源：

EXPERIMENTAL CELL RESEARCH | 1992年 / 201卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0014-4827(92)90306-S

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The amount of histone H1 ° increases relative to other H1 subtypes in terminally differentiated cells, and its expression has been associated with the onset of differentiation. We have studied the kinetics of H1 ° accumulation in mouse erythroleukemia (MEL) cells and found that the levels of H1 ° reflect the rate of cell proliferation rather than the state of differentiation. This suggests that changes in the relative amount of H1 ° during MEL cell differentiation are primarily a consequence of cell cycle arrest. © 1992.

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收藏

页码：531 / 534

页数：4

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