CRF RECEPTOR ANTAGONIST ATTENUATES STRESS-INDUCED NORADRENALINE RELEASE IN THE MEDIAL PREFRONTAL CORTEX OF RATS

被引：40

作者：

SHIMIZU, N ^{[1
]}

NAKANE, H ^{[1
]}

HORI, T ^{[1
]}

HAYASHI, Y ^{[1
]}

机构：

[1] KYUSHU UNIV, FAC MED, DEPT PHYSIOL, FUKUOKA 812, JAPAN

来源：

BRAIN RESEARCH | 1994年 / 654卷 / 01期

关键词：

IN VIVO MICRODIALYSIS; IMMOBILIZATION STRESS; NORADRENALINE RELEASE; MEDIAL PREFRONTAL CORTEX; CORTICOTROPIN RELEASING FACTOR;

D O I：

10.1016/0006-8993(94)91580-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Noradrenaline release in rat medial prefrontal cortex (PFC) was measured using a brain microdialysis technique. Immobilization stress increased noradrenaline release to a maximum level of 248.7 +/- 12.8% of the basal release, which was significantly attenuated by preinjection of alpha-helical CRF(9-41) (50 mu g/rat) into the lateral cerebroventricle. Intracerebroventricular injection of CRF also increased noradrenaline release in the medial PFC. These results suggest that immobilization-stress facilitates noradrenaline release in the medial PFC through activation of the CRF system in the brain.

引用

页码：145 / 148

页数：4

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