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CDNA CLONING AND MESSENGER-RNA EXPRESSION OF THE 6 MOUSE INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEINS

被引：66
作者：
SCHULLER, AGP
GROFFEN, C
VANNECK, JW
ZWARTHOFF, EC
DROP, SLS
机构：
[1] ERASMUS UNIV ROTTERDAM,SOPHIA CHILDRENS HOSP,DEPT PEDIAT,SUBDIV PEDIAT ENDOCRINOL,ROTTERDAM,NETHERLANDS
[2] ERASMUS UNIV ROTTERDAM,SOPHIA CHILDRENS HOSP,DEPT PATHOL,ROTTERDAM,NETHERLANDS
来源：
MOLECULAR AND CELLULAR ENDOCRINOLOGY | 1994年 / 104卷 / 01期
关键词：
INSULIN-LIKE GROWTH FACTOR; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; CLONING; EXPRESSION; DEVELOPMENT; MURINE;
D O I：
10.1016/0303-7207(94)90051-5
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The insulin-like growth factor binding proteins (IGFBPs) comprise a family of six distinct proteins which modulate insulin-like growth factor action. We have isolated cDNAs encoding the six mouse IGFBPs (mIGFBPs). In addition, we studied the mRNA expression of the six mIGFBPs during development and in various adult tissues. Our results show that each of the six mIGFBPs is highly homologous to their human and rat counterparts, whereas only the N and C terminal ends are conserved between the six mIGFBPs. Northern blotting revealed that mIGFBP-2, -3, -4 and -5 genes are already expressed at gestational day 11.5, suggesting a role for these mIGFBPs in embryonal development. In liver, a peak of mIGFBP-1 mRNA expression was found around birth, suggesting a function for mIGFBP-1 in the newborn mouse. Finally, tissue-specific expression of the six mouse IGFBP genes was observed in adult tissues suggesting different roles or modes of actions in adult life.
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页码：57 / 66
页数：10
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