THE RISKS OF HANDLING CYTOTOXIC DRUGS .1. METHODS OF TESTING EXPOSURE

被引：6

作者：

KAIJSER, GP

UNDERBERG, WJM

BEIJNEN, JH

机构：

[1] SLOTERVAART HOSP, 1066 EC AMSTERDAM, NETHERLANDS

[2] ANTONI VAN LEEUWENHOEK HOSP, 1066 CX AMSTERDAM, NETHERLANDS

来源：

PHARMACEUTISCH WEEKBLAD-SCIENTIFIC EDITION | 1990年 / 12卷 / 06期

关键词：

ANTINEOPLASTIC AGENTS; DRUG COMPOUNDING; DRUG CONTAMINATION; EXPOSURE; OCCUPATIONAL; HEALTH-CARE PERSONNEL; MUTAGENICITY TESTS; OCCUPATIONAL HEALTH; PROTECTIVE DEVICES;

D O I：

10.1007/BF01967821

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Results of various biological and physical/chemical tests of the urines or blood of health-care personnel working with cytotoxic drugs are discussed. The outcomes of these tests are conflicting and inconclusive. The physical/chemical tests seem to be an alternative method. However, until now it has not been possible to establish the threshold concentration in urine or blood beneath which no effect has to be expected. Therefore, the interpretation of the concentration of cytotoxic drugs and/or the metabolites in the urine or blood is difficult. As long as one will not be able to provide conclusive data on the health hazards when working with cytotoxic drugs, protective measures have to be taken in order to lower the risk as much as possible.

引用

页码：217 / 227

页数：11

共 141 条

[1] INTERACTIONS OF HISTIDINE-CONTAINING TEST SUBSTANCES AND EXTRACTION METHODS WITH THE AMES MUTAGENICITY TEST [J].