A NEW MEMBER OF THE C1S FAMILY OF COMPLEMENT PROTEINS FOUND IN A BACTERICIDAL FACTOR, RA-REACTIVE FACTOR, IN HUMAN SERUM

被引:56
作者
TAKADA, F
TAKAYAMA, Y
HATSUSE, H
KAWAKAMI, M
机构
[1] KITASATO UNIV,SCH MED,DEPT MOLEC BIOL,1-15-1 KITASATO,SAGAMIHARA,KANAGAWA 228,JAPAN
[2] KITASATO UNIV,SCH MED,DEPT PEDIAT,SAGAMIHARA,KANAGAWA 228,JAPAN
关键词
D O I
10.1006/bbrc.1993.2349
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The Ra-reactive factor (RaRF) found in vertebrate sera activates the C4 and C2 components of complement. The C4/C2-activating component of mouse RaRF has been found to contain a 100-kDa serine protease called P100. In the present study, we cloned a cDNA with cDNA of mouse RaRF P100 as a probe from a human liver cDNA library. An open reading frame of 2097 nucleotides encoding a protein of 699 residues was found in the cloned cDNA of 4489 nucleotides. This protein exhibits 87.4% amino acid homology with mouse P100, and 36.4% and 37.1% homologies with that of the C1r and C1s subcomponents of human complement, respectively. The characteristic modules and domain of C1r and C1s were highly conserved in this protein. This indicates that the P100, together with the C1r and C1s, forms a unique protein family having the same module/domain constitution. © 1993 Academic Press, Inc.
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页码:1003 / 1009
页数:7
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