EFFECTS OF AUTONOMIC NERVOUS SYSTEM-RELATED AGENTS ON THE INTRAVESICAL PRESSURE OF THE BLADDER INSITU IN FEMALE RATS AND AGING

被引:5
作者
TOYOSHIMA, A
ONODERA, S
YOSHINAGA, M
TAKENAGA, K
UCHIYAMA, T
机构
[1] Department of Pharmacology, Toho University School of Medicine, Tokyo
关键词
D O I
10.1254/fpj.96.3_103
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
We investigated the effects of several autonomic nervous system-related agents on the intravesical pressure (IVP) in adult (11-23 weeks old, 200-350 g) and aged (2 years old, 350-770 g) female rats. Acetylcholine induced a dose-dependent and transient increase of IVP, which was competitively antagonized by pirenzepine weakly and by atropine strongly. These results suggest the predominance of M-2 receptors. Adrenaline induced dual actions of decrease and increase of IVP at low and high doses, respectively. Adrenaline (at only high doses), noradrenaline and phenylephrine increased IVP but not clonidine, suggesting the predominance of alpha-1 receptors. Isoproterenol, salbutamol and clenbuterol decreased IVP to same extent and the effect of isoproterenol was markedly antagonized by propranolol and slightly by atenolol, suggesting the predominance of beta-2 receptors. ATP increased IVP dose-dependently but not adenosine, suggesting the predominance of P-2 receptors. Serotonin and prostaglandin F2 alpha also increased IVP. In aged rats, the maximal response to acetylcholine was lower than in adult rats and the decrease in IVP by low doses of adrenaline was not observed. These results suggest that the increase of IVP involves the participation of cholinergic M-2 receptors to a large extent and also serotonergic, adrenergic alpha-1 and purinergic P-2 receptors to some extent and that the responsiveness to acetylcholine is reduced by ageing.
引用
收藏
页码:103 / 115
页数:13
相关论文
共 40 条
[1]   DISTRIBUTION OF ALPHA-ADRENOCEPTORS AND BETA-ADRENOCEPTORS IN HUMAN URINARY-BLADDER [J].
AWAD, SA ;
BRUCE, AW ;
CARROCIA.G ;
DOWNIE, JW ;
LIN, M ;
MARKS, GS .
BRITISH JOURNAL OF PHARMACOLOGY, 1974, 50 (04) :525-529
[2]   COMPARISON OF MUSCARINIC ACETYLCHOLINE BINDING IN THE URINARY-BLADDER AND SUBMANDIBULAR-GLAND OF THE RABBIT [J].
BATRA, S .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 138 (01) :83-88
[3]   ATROPINE RESISTANT EXCITATION OF URINARY-BLADDER - POSSIBILITY OF TRANSMISSION VIA NERVES RELEASING A PURINE NUCLEOTIDE [J].
BURNSTOCK, G ;
SMYTHE, A ;
DUMSDAY, B .
BRITISH JOURNAL OF PHARMACOLOGY, 1972, 44 (03) :451-+
[4]   THE ACTION OF IMIPRAMINE ON THE LOWER URINARY-TRACT OF THE DOG [J].
CREED, KE ;
TULLOCH, AGS .
BRITISH JOURNAL OF UROLOGY, 1982, 54 (01) :5-10
[5]  
DOUGLAS WW, 1975, PHARMACOL BASIS THER, P603
[6]   THE RAT URINARY-BLADDER - A NOVEL PREPARATION FOR THE INVESTIGATION OF CENTRAL OPIOID ACTIVITY INVIVO [J].
DRAY, A .
JOURNAL OF PHARMACOLOGICAL METHODS, 1985, 13 (02) :157-165
[7]   A CONTRIBUTION TO THE INNERVATION OF THE URINARY BLADDER OF THE CAT [J].
EDGE, ND .
JOURNAL OF PHYSIOLOGY-LONDON, 1955, 127 (01) :54-68
[8]   A COMPARISON BETWEEN ATP AND BRADYKININ AS POSSIBLE MEDIATORS OF THE RESPONSES OF SMOOTH-MUSCLE TO NON-ADRENERGIC NON-CHOLINERGIC NERVES [J].
FERRERO, JD ;
COCKS, T ;
BURNSTOCK, G .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1980, 63 (04) :295-302
[9]   BINDING AND FUNCTIONAL PROFILES OF THE SELECTIVE M1 MUSCARINIC RECEPTOR ANTAGONISTS TRIHEXYPHENIDYL AND DICYCLOMINE [J].
GIACHETTI, A ;
GIRALDO, E ;
LADINSKY, H ;
MONTAGNA, E .
BRITISH JOURNAL OF PHARMACOLOGY, 1986, 89 (01) :83-90
[10]   MUSCARINIC RECEPTOR SUBTYPES - M1 AND M2 BIOCHEMICAL AND FUNCTIONAL-CHARACTERIZATION [J].
HAMMER, R ;
GIACHETTI, A .
LIFE SCIENCES, 1982, 31 (26) :2991-2998