CENTRAL BEHAVIORAL INTERACTIONS BETWEEN ETHANOL, (-)-NICOTINE, AND (-)-COTININE IN MICE

被引:25
作者
DAR, MS [1 ]
LI, CX [1 ]
BOWMAN, ER [1 ]
机构
[1] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL,RICHMOND,VA 23298
关键词
(-)-NICOTINE; ETHANOL; BEHAVIORAL INTERACTIONS; INTRACEREBROVENTRICULAR; (-)-COTININE; MICE;
D O I
10.1016/0361-9230(93)90314-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A high correlation between alcohol use and smoking has long been suggested by epidemiological data. We examined the potential behavioral interactions between ethanol and nicotine using ethanol-induced motor incoordination as the test response in mice. Effect of pretreatment of various doses of (-)-nicotine, (-)-cotinine, a major metabolite of nicotine, and (+)-nicotine administered ICV on ethanol (IP)-induced motor incoordination was investigated. (-)-Nicotine (0. 19, 0.38, 0.77 and, 1.54 nmoles ICV) produced significant attenuation of motor incoordination due to ethanol (2 g/kg IP) in a nearly dose-related manner which was blocked by ICV hexamethonium and trimethaphan, both purported nicotinic antagonists. (-)-Cotinine (0.35, 0.70, 1.41 nmole ICV) produced similar attenuation but was less potent than (-)-nicotine. Attenuation by (+)-nicotine(0.19,0.38, and 0.77 nmoles ICV) was also significant but only at 0.77 nmole dose level. (+)-Nicotine-induced attenuation of motor incoordination by ethanol was antagonized by nicotinic antagonists. Data obtained suggest a central behavioral interaction between ethanol and nicotine at least through the participation of cholinergic nicotinic receptors.
引用
收藏
页码:23 / 28
页数:6
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