COMPARISON OF GRANISETRON ALONE AND GRANISETRON PLUS DEXAMETHASONE IN THE PROPHYLAXIS OF CYTOTOXIC-INDUCED EMESIS

被引:39
作者
CARMICHAEL, J
BESSEL, EM
HARRIS, AL
HUTCHEON, AW
DAWES, PJDK
DANIELS, S
机构
[1] SMITHKLINE BEECHAM PHARMACEUT,WELWYN GARDEN CIT AL7 1EY,HERTS,ENGLAND
[2] NOTTINGHAM CITY HOSP TRUST,CRC,ACAD UNIT CLIN ONCOL,NOTTINGHAM NG5 1PB,ENGLAND
[3] UNIV OXFORD,CHURCHILL HOSP,CLIN ONCOL UNIT,OXFORD OX3 7LJ,ENGLAND
[4] ABERDEEN ROYAL INFIRM,ABERDEEN AB9 2ZB,SCOTLAND
[5] NEWCASTLE GEN HOSP,NEWCASTLE TYNE NE4 6BE,TYNE & WEAR,ENGLAND
关键词
D O I
10.1038/bjc.1994.465
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Two hundred and seventy-eight adult chemonaive patients receiving moderately emetogenic chemotherapy were randomly allocated to receive either intravenous (i.v.) granisetron 3 mg plus i.v. dexamethasone 8 mg or i.v. granisetron 3 mg plus i.v. placebo dexamethasone prior to chemotherapy. Eighty-two per cent of all patients recruited were female, and 91% of all patients consumed less than 10 units of alcohol per week, suggesting a study population with an increased risk of nausea and vomiting. In the first 24 h 85% of patients who received granisetron plus dexamethasone were complete responders compared with 75.9% of the patients receiving granisetron alone (P = 0.053). There were statistically significant improvements in complete response over 7 days (P = 0.029) and in the numbers of patients receiving rescue antiemetic (P = 0.0004). Toxicity was minimal with no significant differences between treatment groups. These results confirm the antiemetic acitivity of granisetron and show that it has an additive effect in combination with dexamethasone.
引用
收藏
页码:1161 / 1164
页数:4
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