INDUCTION OF CONSTITUTIVE HEAT-SHOCK PROTEIN-73 MESSENGER-RNA IN THE DENTATE GYRUS BY SEIZURES

被引：27

作者：

WONG, ML

WEISS, SRB

GOLD, PW

DOI, SQ

BANERJEE, S

LICINIO, J

LAD, R

POST, RM

SMITH, MA

机构：

[1] NIMH,CLIN NEUROENDOCRINOL BRANCH,BLDG 36,ROOM 2D 15,9000 ROCKVILLE PIKE,BETHESDA,MD 20892

[2] NIDDK,METAB DIS BRANCH,BETHESDA,MD 20892

[3] NIMH,BIOL PSYCHIAT BRANCH,BETHESDA,MD 20892

来源：

MOLECULAR BRAIN RESEARCH | 1992年 / 13卷 / 1-2期

关键词：

HEAT SHOCK PROTEIN; MESSENGER RNA; COCAINE; KINDLING; ELECTROCONVULSIVE SEIZURE; DENTATE GYRUS; HIPPOCAMPUS; INSITU HYBRIDIZATION;

D O I：

10.1016/0169-328X(92)90040-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the effects of generalized seizures on heat shock protein (hsp) mRNA induction in the rat brain using in situ hybridization. Seizures induced by electroconvulsive shock, electrical or cocaine kindling caused a selective induction of the constitutive hsp 73 gene in the dentate gyrus. In these seizure paradigms, not thought to induce widespread tissue damage, neither the heat-inducible hsp 72 gene nor a member of the hsp 90 family (hsp 84) were induced. Hsp 73 may play a role in the adaptation and/or in the maintainence of dentate granule cell integrity following seizures.

引用

页码：19 / 25

页数：7

共 38 条

[1] INTERACTION OF HSP-70 WITH NEWLY SYNTHESIZED PROTEINS - IMPLICATIONS FOR PROTEIN FOLDING AND ASSEMBLY [J].