ENDOGENOUS DIGITALIS-LIKE FACTORS

被引:25
作者
SCHONER, W
机构
[1] Institut för Biochemie und Endokrinologie, Fachbereich Veterinärmedizin, Justus-Liebig-Universität Gießen, D-6300 Giessen
基金
英国医学研究理事会;
关键词
ENDOGENOUS DIGITALIS-LIKE FACTOR; OUABAIN; DIGOXIN; CARDIAC GLYCOSIDES; NATRIURETIC FACTOR; ESSENTIAL HYPERTENSION;
D O I
10.3109/10641969209036220
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The postulate of a natriuretic factor inhibiting the sodium pump in the kidney led to the detection of increased concentrations of endogenous digitalis-like factors in blood after salt loading, in essential hypertension, in pregnancy-induced hypertension and in chronic hypervolaemia. The recent isolation of ouabain or a close isomer thereof from human plasma and the demonstration of a compound similar if not identical to digoxin in adrenals and human urine shows that mammals like non-vertebrates and toads may synthesize cardiac glycosides in their adrenals and possibly in hypothalamus. The hypothalamus also forms other compounds of unknown structure which bind to the cardiac glycoside receptor site. The differential functions of endogenously formed ouabain and of a digoxin-like substance are unclear. The detailed knowledge of the physiological role of both endogenously formed cardiac glycosides in the regulation of blood pressure has still to be worked out.
引用
收藏
页码:767 / 814
页数:48
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