CEPHALOSPORIN-C BIOSYNTHESIS - ON THE MECHANISM OF HYDROXYLATION OF DEACETOXYCEPHALOSPORIN-C TO DEACETYLCEPHALOSPORIN-C

被引:4
作者
BALDWIN, JE [1 ]
ADLINGTON, RM [1 ]
APLIN, RT [1 ]
CROUCH, NP [1 ]
WILKINSON, R [1 ]
机构
[1] UNIV OXFORD,OXFORD CTR MOLEC SCI,OXFORD OX1 3QY,ENGLAND
关键词
D O I
10.1016/S0040-4020(01)89876-8
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Incubation of an equal mixture of deacetoxycephalosporin C and [3'-H-2(3)]deacetoxycephaloporin C with partially purified deacetoxycephalosporin C / deacetylcephalosporin C synthase from Cephalosporium acremonium CO728 in a mixed competitive kinetic isotope effect experiment resulted in enzymic discrimination between labelled and unlabelled substrates.
引用
收藏
页码:6853 / 6862
页数:10
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