SYNTHESES OF ACETOMYCIN-RELATED (2R,3S,4R)-2-ACETOXY-4-ACETYL-3,4-DIMETHYLTETRAHYDROFURAN AND (2S,3R,4R)-2-ACETOXY-4-ACETYL-3,4-DIMETHYLTETRAHYDROFURAN AND THEIR GROWTH-INHIBITION ACTIVITY AGAINST TUMOR-CELLS

被引：6

作者：

ISHIHARA, J ^{[1
]}

TERATO, N ^{[1
]}

SUMINO, A ^{[1
]}

TADANO, K ^{[1
]}

OGAWA, S ^{[1
]}

机构：

[1] KEIO UNIV, DEPT APPL CHEM, 3-14-1 HIYOSHI, KOHOKU KU, YOKOHAMA, KANAGAWA 223, JAPAN

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 1993年 / 66卷 / 05期

关键词：

D O I：

10.1246/bcsj.66.1441

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The syntheses of two tetrahydrofuran derivatives structurally related to the antitumor agent acetomycin are described. These compounds were synthesized starting from known D-glucose-derived functionalized tetrahydrofuran derivatives.

引用

页码：1441 / 1450

页数：10

共 14 条

[11] CLAISEN REARRANGEMENT OF (Z)-3-DEOXY-3-C-[(HYDROXYMETHYL)METHYLENE]-1,2-5,6-DI-O-ISOPROPYLIDENE-ALPHA-D-RIBO-HEXOFURANOSE WITH TRIETHYL ORTHOPROPIONATE [J].

TADANO, K ;

ISHIHARA, J ;

YAMADA, H ;

OGAWA, S .

JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (05) :1223-1227

[12]

Tadano K., 1992, STUDIES NATURAL PROD, V10, P405

[13] ORTHO ESTER CLAISEN REARRANGEMENTS OF 3 3-C-(HYDROXYMETHYL)METHYLENE DERIVATIVES OF HEXOFURANOSE - STEREOSELECTIVE INTRODUCTION OF A QUATERNARY CENTER ON C-3 OF D-RIBO-HEXOFURANOSE, L-LYXO-HEXOFURANOSE, AND D-ARABINO-HEXOFURANOSE [J].

TADANO, KI ;

IDOGAKI, Y ;

YAMADA, H ;

SUAMI, T .

JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (07) :1201-1210

[14]

UHR H, 1985, J ANTIBIOT, V38, P1685

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