THE EFFECT OF WATER TEMPERATURE ON IMMOBILITY IN THE FORCED SWIMMING TEST IN RATS

被引:28
作者
JEFFERYS, D [1 ]
FUNDER, J [1 ]
机构
[1] BAKER MED RES INST,MELBOURNE,AUSTRALIA
关键词
FORCED SWIMMING TEST; WATER TEMPERATURE; GLUCOCORTICOID; KAPPA-OPIOID RECEPTOR; SELECTIVE; THYROID HORMONE; GLUCOSE;
D O I
10.1016/0014-2999(94)90761-7
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In the Porsolt swimming test intact rats acquire and retain the immobile response indistinguishably at 25 and 30 degrees C; at both temperatures retention is abolished by administration of the glucocorticoid antagonist RU38486 and the kappa-selective opiate receptor antagonist MR2266 when given together, but not when either is given alone. At 20 degrees C, however, the animals do not acquire the response, and have levels of retention significantly lower than at the higher temperature. This deficit is not restored by administration of glucocorticoids, kappa-opioid receptor-selective agonists, thyroid hormone or glucose.
引用
收藏
页码:91 / 94
页数:4
相关论文
共 11 条
[1]   THE FORCED SWIMMING TEST - EFFECTS OF GLUCOSE-ADMINISTRATION ON THE RESPONSE TO FOOD-DEPRIVATION AND ADRENALECTOMY [J].
JEFFERYS, D ;
FUNDER, JW .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 205 (03) :267-269
[2]   BEHAVIORAL-EFFECT OF ADRENALECTOMY - REVERSAL BY GLUCOCORTICOIDS OR [D-ALA2,MET5]ENKEPHALINAMIDE [J].
JEFFERYS, D ;
COPOLOV, D ;
IRBY, D ;
FUNDER, J .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1983, 92 (1-2) :99-103
[3]   GLUCOCORTICOIDS, ADRENAL-MEDULLARY OPIOIDS, AND THE RETENTION OF A BEHAVIORAL-RESPONSE AFTER STRESS [J].
JEFFERYS, D ;
FUNDER, JW .
ENDOCRINOLOGY, 1987, 121 (03) :1006-1009
[4]   A KAPPA-SELECTIVE OPIOIDERGIC PATHWAY IS INVOLVED IN THE REVERSAL OF A BEHAVIORAL-EFFECT OF ADRENALECTOMY [J].
JEFFERYS, D ;
BOUBLIK, J ;
FUNDER, JW .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1985, 107 (03) :331-335
[5]  
JEFFERYS D, 1989, ENDOCRINOLOGY, V123, P1103
[6]   THE THYROADRENAL AXIS, FOOD-DEPRIVATION AND RETENTION OF A BEHAVIORAL-RESPONSE [J].
JEFFERYS, DE ;
FUNDER, JW .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 239 (1-3) :189-193
[7]  
PEETERS B, 1991, PHYSIOL BEHAV, V51, P127
[8]  
PORSOLT RD, 1977, ARCH INT PHARMACOD T, V229, P327
[9]   BEHAVIORAL DESPAIR IN RATS - NEW MODEL SENSITIVE TO ANTIDEPRESSANT TREATMENTS [J].
PORSOLT, RD ;
ANTON, G ;
BLAVET, N ;
JALFRE, M .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 47 (04) :379-391
[10]   GLUCOCORTICOIDS FACILITATE THE RETENTION OF ACQUIRED IMMOBILITY DURING FORCED SWIMMING [J].
VELDHUIS, HD ;
DEKORTE, CCMM ;
DEKLOET, ER .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1985, 115 (2-3) :211-217