TISSUE-NONSPECIFIC ALKALINE-PHOSPHATASE PARTICIPATES IN THE ESTABLISHMENT AND GROWTH OF FEATHER GERMS IN EMBRYONIC CHICK SKIN CULTURES

被引：12

作者：

CRAWFORD, K ^{[1
]}

WEISSIG, H ^{[1
]}

BINETTE, F ^{[1
]}

MILLAN, JL ^{[1
]}

GOETINCK, PF ^{[1
]}

机构：

[1] LA JOLLA CANC RES FDN,CANC RES CTR,LA JOLLA,CA 92037

来源：

DEVELOPMENTAL DYNAMICS | 1995年 / 204卷 / 01期

关键词：

FEATHER PATTERN FORMATION; EMBRYONIC SKIN CULTURES; ALKALINE PHOSPHATASE GENE;

D O I：

10.1002/aja.1002040107

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Alkaline phosphatase activity is present in the mesoderm of embryonic chick skin and becomes spatially restricted to the dermal condensation of the developing feather germs, Inhibitors to tissue-nonspecific (liver/bone/kidney), but not intestinal, alkaline phosphatase inhibit the establishment and growth of feather germs in cultured skins, A window of maximum sensitivity to the inhibitor was observed to be the first day of culture when early development and establishment of pattern takes place. The cDNA for the avian tissue-nonspecific alkaline phosphatase was cloned and sequenced, and Southern analysis revealed a single copy of this gene in the avian genome. Northern analysis revealed that a 2.8 kb transcript for this form of alkaline phosphatase is present in developing skin. (C) 1995 Wiley-Liss, Inc.

引用

页码：48 / 56

页数：9

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