AN EFFICIENT AND CONCISE ENTRY TO (-)-4,5-DIHYDROXY-D-THREO-L-NORVALINE - FORMAL SYNTHESIS OF CLAVALANINE

被引:24
作者
ARIZA, J [1 ]
FONT, J [1 ]
ORTUNO, RM [1 ]
机构
[1] UNIV AUTONOMA BARCELONA,DEPT QUIM,UNITAT QUIM ORGAN,E-08193 BARCELONA,SPAIN
关键词
D O I
10.1016/0040-4039(91)85018-Z
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The title amino acid (2) has been synthesized for the first time in a seven-step sequence from D-ribonolactone, in 20% overall yield. Since the N-carbamoyl derivative of (2) in its gamma -lactone form has been used to prepare clavalanine, a formal total synthesis of this antibiotic is derived.
引用
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页码:1979 / 1982
页数:4
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