INTERACTION OF ADENINE-NUCLEOTIDES WITH THE ADENINE-NUCLEOTIDE TRANSLOCASE REGULATES THE DEVELOPMENTAL-CHANGES IN PROTON CONDUCTANCE OF THE INNER MITOCHONDRIAL-MEMBRANE

被引：19

作者：

VALCARCE, C ^{[1
]}

CUEZVA, JM ^{[1
]}

机构：

[1] UNIV AUTONOMA MADRID, CSIC, CTR BIOL MOLEC, DEPT BIOL MOLEC, E-28049 MADRID, SPAIN

来源：

FEBS LETTERS | 1991年 / 294卷 / 03期

关键词：

ATP/ADP ANTIPORTER; ADENINE NUCLEOTIDE; PROTON CONDUCTANCE; PASSIVE PROTON PERMEABILITY; LIVER DEVELOPMENT;

D O I：

10.1016/0014-5793(91)81435-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

2-h-old neonatal liver mitochondria, when depleted of adenine nucleotides, showed an 'ohmic' current-voltage relationship and a higher passive proton permeability of the membrane, resembling fetal mitochondrial behaviors for the proton conductance. Incubation of fetal mitochondria with ATP, GDP or carboxyatractyloside promoted a significant reduction in the passive proton permeability of the membrane and the appearance of the characteristic biphasic behavior for the proton conductance. It is concluded that the postnatal increase in intramitochondrial adenine nucleotide concentration promotes, by the interaction of the nucleotides with the adenine nucleotide translocase, the reduction in the passive proton permeability of the mitochondrial membrane, allowing efficient energy conservation in the neonatal liver.

引用

页码：225 / 228

页数：4