SAFETY AND EFFICACY OF REPEATED SEQUENTIAL ADMINISTRATIONS OF RE-186(SN)HEDP AS PALLIATIVE THERAPY FOR PAINFUL SKELETAL METASTASES - INITIAL CASE-REPORTS OF 2 PATIENTS

被引：19

作者：

ENGLARO, EE

SCHRODER, LE

THOMAS, SR

WILLIAMS, CC

MAXON, HR

机构：

[1] UNIV CINCINNATI,MED CTR,EUGENE L SAENGER RADIOISOTOPE LAB,MAIL LOCAT 577,234 GOODMAN ST,CINCINNATI,OH 45267

[2] UNIV CINCINNATI,MED CTR,DEPT RADIOL,DIV MED PHYS,CINCINNATI,OH 45267

[3] UNIV CINCINNATI,MED CTR,DEPT INTERNAL MED,DIV HEMATOL ONCOL,CINCINNATI,OH 45267

来源：

CLINICAL NUCLEAR MEDICINE | 1992年 / 17卷 / 01期

关键词：

D O I：

10.1097/00003072-199201000-00012

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Single intravenous injections of 30 to 35 mCi (1,110 to 1,295 MBq) of Re-186(Sn)HEDP previously have been shown to result in palliation of painful skeletal metastases from prostate cancer. There are no reports of patients receiving repetitive Re-186(Sn)HEDP therapy. We have followed two such patients who received multiple (five to seven) injections of Re-186(Sn)HEDP at 2-month intervals. Each experienced a sustained decrease in both pain and analgesic intake. The only evident clinical or biochemical toxicity was a mild progressive decline in their total platelet counts.

引用

页码：41 / 44

页数：4

共 2 条

[1] RE-186(SN) HEDP FOR TREATMENT OF MULTIPLE METASTATIC FOCI IN BONE - HUMAN BIODISTRIBUTION AND DOSIMETRIC STUDIES [J].

MAXON, HR ;

DEUTSCH, EA ;

THOMAS, SR ;

LIBSON, K ;

LUKES, SJ ;

WILLIAMS, CC ;

ALI, S .

RADIOLOGY, 1988, 166 (02) :501-507

[2] RE-186(SN) HEDP FOR TREATMENT OF PAINFUL OSSEOUS METASTASES - INITIAL CLINICAL-EXPERIENCE IN 20 PATIENTS WITH HORMONE-RESISTANT PROSTATE-CANCER [J].

MAXON, HR ;

SCHRODER, LE ;

THOMAS, SR ;

HERTZBERG, VS ;

DEUTSCH, EA ;

SCHER, HI ;

SAMARATUNGA, RC ;

LIBSON, KF ;

WILLIAMS, CC ;

MOULTON, JS ;

SCHNEIDER, HJ .

RADIOLOGY, 1990, 176 (01) :155-159

← 1 →