CDC37 IS REQUIRED FOR ASSOCIATION OF THE PROTEIN-KINASE CDC28 WITH G(1) AND MITOTIC CYCLINS

被引:122
作者
GERBER, MR [1 ]
FARRELL, A [1 ]
DESHAIES, RJ [1 ]
HERSKOWITZ, I [1 ]
MORGAN, DO [1 ]
机构
[1] UNIV CALIF SAN FRANCISCO, DEPT BIOCHEM & PHYSIOL, SAN FRANCISCO, CA 94143 USA
关键词
CELL CYCLE; CYCLIN-DEPENDENT KINASE;
D O I
10.1073/pnas.92.10.4651
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Studies of the temperature-sensitive cdc37-1 mutant of Saccharomyces cerevisiae suggest that Cdc37 is required for passage through the G(1) phase of the cell cycle, but its precise function is not known. We have investigated the role of Cdc37 in the regulation of the cyclin-dependent protein kinase Cdc28. We find that G(1) arrest in the cdc37-1 mutant is accompanied by a decrease in the Cdc28 activity associated with the G(1) cyclin Cln2. This defect appears to be caused by a decrease in the binding of Cdc28 and Cln2. cdc37-1 mutants also exhibit a defect in the binding and activation of Cdc28 by the mitotic cyclin Clb2. Thus Cdc37 may be a regulator that is required for the association of Cdc28 with multiple cyclins.
引用
收藏
页码:4651 / 4655
页数:5
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