EFFECT OF PERGOLIDE ON ENDOGENOUS AND EXOGENOUS L-DOPA METABOLISM IN THE RAT STRIATUM - A MICRODIALYSIS STUDY

被引:16
作者
DETHY, S [1 ]
LAUTE, MA [1 ]
LUXEN, A [1 ]
HILDEBRAND, J [1 ]
GOLDMAN, S [1 ]
机构
[1] FREE UNIV BRUSSELS,HOP ERASME,PET BIOMED CYCLOTRON UNIT,B-1070 BRUSSELS,BELGIUM
关键词
BRAIN MICRODIALYSIS; DOPAMINE; PERGOLIDE; DOPAMINERGIC AGONISTS; STRIATUM;
D O I
10.1007/BF01271541
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We used a model of intrastriatal microdialysis in freely moving rats to study the effect of pergolide, a mixed D-1/D-2 dopamine (DA) receptor agonist with predominant D-2 action in vivo, on the biotransformation of endogenous and exogenous L-DOPA. Levels of L-DOPA, DA, DOPAC, HVA and 5-HIAA were measured by high performance liquid chromatography. Pergolide (50 mu g/kg, i.p.) caused a 47%, 65% and 70% decrease in basal striatal extracellular (EC) levels of DOPAC, HVA and DA, respectively. L-DOPA (100 mg/kg, i.p.), injected 2 hours after carbidopa, produced significant increase in EC levels of L-DOPA, DOPAC, HVA and DA in rats with and without local perfusion of 10(-4) M pergolide. The DOPAC peak value was lower and was reached 60 minutes later in the group with pergolide. This study demonstrated inhibitory effects of pergolide on endogenous DA release and influence of pergolide on exogenous L-DOPA biotransformation.
引用
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页码:1 / 11
页数:11
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