MANAGEMENT OF HYPOTHALAMIC GLIOMAS IN CHILDREN - AN ANALYSIS OF 33 CASES

被引：75

作者：

RODRIGUEZ, LA

EDWARDS, MSB

LEVIN, VA

机构：

[1] UNIV CALIF SAN FRANCISCO,SCH MED,DEPT NEUROL SURG,1360 9TH AVE,SUITE 210,SAN FRANCISCO,CA 94122

[2] UNIV CALIF SAN FRANCISCO,SCH MED,BRAIN TUMOR RES CTR,SAN FRANCISCO,CA 94122

[3] UNIV CALIF SAN FRANCISCO,SCH MED,DIV PEDIAT NEUROSURG,SAN FRANCISCO,CA 94122

[4] UNIV CALIF SAN FRANCISCO,SCH MED,DEPT PEDIAT,SAN FRANCISCO,CA 94122

来源：

NEUROSURGERY | 1990年 / 26卷 / 02期

关键词：

chemotherapy; chiasmatic-hypothalamic glioma; neurofibromatosis; radiation therapy;

D O I：

10.1227/00006123-199002000-00010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The cases of 33 children with hypothalamic-chiasmatic gliomas are reviewed. Radiation therapy produced clinical or radiographic improvement in 11 (46%) of 24 patients. Progression was documented in 18 patients (54%). Overall, the median time to tumor progression was 60 months; it was 70 months in patients who received radiation therapy and 30 months in those who did not (P < 0.05). Chemotherapy, either given initially or at the time of progression, caused the tumor to respond or to stabilize in 10 patients. Partial resection of the tumor led to improvement in 3 of 12 patients, obviating the need for a shunt in 2 of them; there were no deaths and postoperative morbidity was transient and minimal (diabetes insipidus, intraventricular hemorrhage, and left hemiparesis in one patient each). The 5- and 10-year survival probabilities were 93 and 74%, respectively. Patients with neurofibromatosis had a better prognosis.

引用

页码：242 / 247

页数：6

共 24 条

[11] GLIOMA OF THE OPTIC NERVE - AS A MANIFESTATION OF VONRECKLINGHAUSENS DISEASE [J].