ZINC ACUTELY AND TEMPORARILY INHIBITS ADRENAL CORTISOL SECRETION IN HUMANS - A PRELIMINARY-REPORT

被引：22

作者：

BRANDAONETO, J

DEMENDONCA, BB

SHUHAMA, T

MARCHINI, JS

PIMENTA, WP

TORNERO, MTT

机构：

[1] UNIV SAO PAULO,FAC MED,DEPT INTERNAL MED,BR-05403 SAO PAULO,SP,BRAZIL

[2] UNIV SAO PAULO,FAC CIENCIAS FARMACEUT RIBEIRAO PRETO,DEPT PHYS CHEM,BR-14049 RIBEIRAO PRETO,SP,BRAZIL

来源：

BIOLOGICAL TRACE ELEMENT RESEARCH | 1990年 / 24卷 / 01期

关键词：

Acute hyperzincemia; normal individuals; plasma zinc and cortisol levels; zinc supplement; effects of on cortisol secretion;

D O I：

10.1007/BF02789143

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hypo-and hyperzincemia has been reported to cause alterations in the adrenal secretion. To determine the acute effect of zinc on cortisol levels, we studied 27 normal individuals of both sexes aged 20-27 y after a 12-h fast. The tests were initiated at 7:00 am when an antecubital vein was punctured and a device for infusion was installed and maintained with physiological saline. Zinc was administered orally at 8:00 am. Subjects were divided into an experimental group of 13 individuals who received doses of 25, 37.5, and 50 mg of zinc and a control group of 14 individual who received 20 mL of physiological saline. Serial blood samples were collected over a period of 240 min after basal samples (-30 and 0 min). We detected an acute inhibitory effect of zinc on cortisol secretion during 240 min of the study period in the experimental group. © 1990 Humana Press Inc.

引用

页码：83 / 89

页数：7

共 11 条

[1] A CRITICAL PHYSIOLOGICAL-ROLE OF ZINC IN THE STRUCTURE AND FUNCTION OF BIOMEMBRANES [J].