4-(SULFONYLAMINO)PHENYL ALPHA-D-GLUCOPYRANOSIDES AS COMPETITIVE INHIBITORS OF YEAST ALPHA-GLUCOSIDASE

被引：8

作者：

BRIGGS, JC ^{[1
]}

HAINES, AH ^{[1
]}

TAYLOR, RJK ^{[1
]}

机构：

[1] UNIV E ANGLIA,SCH CHEM SCI,NORWICH NR4 7TJ,NORFOLK,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1993年 / 18期

关键词：

D O I：

10.1039/c39930001410

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Certain members of a series of 4-(sulfonylamino)phenyl alpha-D-glucopyranosides are extremely good competitive inhibitors of yeast alpha-glucosidase and, remarkably, 4-(4-nitrophenylsulfonylamino)phenyl and 4-(2-naphthylsulfonylamino)phenyl alpha-D-glucopyranoside (K(i) 4.8 and 3.1 mumol dm-3, respectively) are superior to 1-deoxynojirimycin (K(i) 14.6 mumol dm-3) against this enzyme.

引用

页码：1410 / 1411

页数：2

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