INTERFERON-ALPHA,BETA AND TUMOR-NECROSIS-FACTOR-ALPHA ENHANCE THE FREQUENCY OF MINIATURE END-PLATE POTENTIALS AT RAT NEUROMUSCULAR-JUNCTION

被引：13

作者：

CARATSCH, CG

SANTONI, A

EUSEBI, F

机构：

[1] UNIV ROMA LA SAPIENZA,DIPARTIMENTO MED SPERIMENTALE,I-00161 ROME,ITALY

[2] IRE,FISIOPATOL LAB,I-00158 ROME,ITALY

来源：

NEUROSCIENCE LETTERS | 1994年 / 166卷 / 01期

关键词：

INTERFERON; TUMOR NECROSIS FACTOR; NEUROMODULATION; MAMMALIAN NEUROMUSCULAR JUNCTION; ELECTROPHYSIOLOGY;

D O I：

10.1016/0304-3940(94)90849-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of the two cytokines, rat interferon-alpha, and human tumor necrosis factor-alpha, were studied at the rat neuromuscular junction by using classical electrophysiological techniques. Both cytokines in a similar way at concentrations of 2,000 and 35,000 U/ml, respectively, increased transiently and with a relatively long delay (15 to 25 min) the frequency of mimiature endplate potentials. The observed effects may be related to complex second messenger mechanisms and contribute to modulation and plasticity of neurotransmission.

引用

页码：97 / 100

页数：4

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