DECREASED CYCLOSPORINE-A ABSORPTION AFTER TREATMENT WITH GOLYTELY LAVAGE SOLUTION IN RATS

被引：1

作者：

SANTA, T ^{[1
]}

NISHIHARA, K ^{[1
]}

HORIE, S ^{[1
]}

KOTAKI, H ^{[1
]}

SAWADA, Y ^{[1
]}

KAWABE, K ^{[1
]}

IGA, T ^{[1
]}

机构：

[1] TOKYO UNIV HOSP, FAC MED, DEPT UROL, BUNKYO KU, TOKYO 113, JAPAN

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1994年 / 46卷 / 07期

关键词：

D O I：

10.1111/j.2042-7158.1994.tb03866.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recently we observed a case in which the cyclosporin A absorption decreased after treatment with GoLytely lavage solution in a kidney transplant patient. In this study, we confirmed the decrease of the blood concentration of cyclosporin A after oral administration by GoLytely (Macrogol 3350) based on experiments with rats. The peak blood cyclosporin A concentration, and the area under the blood drug concentration-time curve from 0 to 24 h in the GoLytely-administered group were significantly lower than the control group. In the case of gastrointestinal dysfunction such as diarrhoea, or in treatment with laxatives such as GoLytely lavage solution, whole blood cyclosporin levels must be carefully monitored, and intravenous cyclosporin A may be more suitable for providing adequate immunosuppression.

引用

页码：606 / 607

页数：2

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