SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF MERIBENDAN AND RELATED HETEROCYCLIC BENZIMIDAZOLO-PYRIDAZINONES

被引：67

作者：

JONAS, R ^{[1
]}

KLOCKOW, M ^{[1
]}

LUES, I ^{[1
]}

PRUCHER, H ^{[1
]}

SCHLIEP, HJ ^{[1
]}

WURZIGER, H ^{[1
]}

机构：

[1] E MERCK AG,PRECLIN PHARMACEUT RES LABS,FRANKFURTER STR 250,W-6100 DARMSTADT,GERMANY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1993年 / 28卷 / 02期

关键词：

BENZIMIDAZOLE; CALCIUM SENSITIVITY; CARDIOTONICS; INOTROPES; PHOSPHODIESTERASE; PAPILLARY MUSCLE; PYRIDAZINONE;

D O I：

10.1016/0223-5234(93)90005-Y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of new heterocyclic benzimidazolo-pyridazinones is described. The new compounds were evaluated as inotropic agents with 'calcium-sensitizing' effects. 5-Methyl-6-[2-(3-pyrazolyl)-5-benzimidazolyl]-2,3,4,5-tetrahydro-pyridazin-3-one hydrochloride (meribendan) turned out to be the most interesting compound and was chosen for development as a positive inotrope.

引用

页码：129 / 140

页数：12

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