ENANTIOSELECTIVE SYNTHESIS OF (S)-TRANS-GAMMA-BUTENYNYL GAMMA-AMINOBUTYRIC-ACID (GABA)

被引：15

作者：

HOLMES, AB ^{[1
]}

TABOR, AB ^{[1
]}

BAKER, R ^{[1
]}

机构：

[1] MERCK SHARP & DOHME NEUROSCI RES CTR,HARLOW CM20 2QR,ESSEX,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1991年 / 12期

关键词：

D O I：

10.1039/p19910003307

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantioselective synthesis of (S)-trans-gamma-butenynyl gamma-aminobutyric acid (GABA) 1 by phthalimide displacement of the (R)-alcohol 9 (generated from the acetal 3) is reported. Novel hydride reductions of the pentadiynylic ether 3 to the trans-enyne 5 are reported and discussed.

引用

页码：3307 / 3313

页数：7

共 24 条

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TABOR, AB ;

HOLMES, AB ;

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[22]

TABOR AB, 1991, J CHEM SOC PERK T 1, P3307

[23]

UCHIDA K, 1976, J ORG CHEM, V41, P2215, DOI 10.1021/jo00874a034

[24] DIALKYLALUMINIUMHYDRIDE ALS STERISCH SPEZIFISCHE REDUKTIONSMITTEL FUR ACETYLENE [J].

WILKE, G ;

MULLER, H .

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