EPOXOMICIN, A NEW ANTITUMOR AGENT OF MICROBIAL ORIGIN

被引：177

作者：

HANADA, M

SUGAWARA, K

KANETA, K

TODA, S

NISHIYAMA, Y

TOMITA, K

YAMAMOTO, H

KONISHI, M

OKI, T

机构：

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 11期

关键词：

D O I：

10.7164/antibiotics.45.1746

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

An actinomycete strain No. Q996-17 produced a novel compound, epoxomicin, which exhibited in vivo antitumor activity against B16 melanoma. Structural studies indicated that it is a new member of the epoxy-beta-aminoketone group, and is closely related to eponemycin.

引用

页码：1746 / 1752

页数：7

共 4 条

[1] MCMARTHY AJ, 1989, BERGEYS MANUAL SYSTE, V4, P2552
[2] EPONEMYCIN, A NOVEL ANTIBIOTIC, IS A HIGHLY POWERFUL ANGIOGENESIS INHIBITOR
OIKAWA, T
HASEGAWA, M
SHIMAMURA, M
ASHINO, H
MUROTA, S
MORITA, I
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 181 (03) : 1070 - 1076
[3] BMY-28438 (3,7-DIHYDROXYTROPOLONE), A NEW ANTITUMOR ANTIBIOTIC ACTIVE AGAINST B-16 MELANOMA .1. PRODUCTION, ISOLATION, STRUCTURE AND BIOLOGICAL-ACTIVITY
SUGAWARA, K
OHBAYASHI, M
SHIMIZU, K
HATORI, M
KAMEI, H
KONISHI, M
OKI, T
KAWAGUCHI, H
[J]. JOURNAL OF ANTIBIOTICS, 1988, 41 (07) : 862 - 868
[4] EPONEMYCIN, A NEW ANTIBIOTIC ACTIVE AGAINST B16 MELANOMA .1. PRODUCTION, ISOLATION, STRUCTURE AND BIOLOGICAL-ACTIVITY
SUGAWARA, K
HATORI, M
NISHIYAMA, Y
TOMITA, K
KAMEI, H
KONISHI, M
OKI, T
[J]. JOURNAL OF ANTIBIOTICS, 1990, 43 (01) : 8 - 18

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