DNA REARRANGEMENTS AND ALTERED TRANSCRIPTS OF THE MLL GENE IN A HUMAN T-ALL CELL-LINE KARPAS-45 WITH A T(X11) (Q13Q23) TRANSLOCATION

Translocations involving chromosome band 11q23 are found in both lymphoid and myeloid leukemias as well as in lymphomas, and we have recently reported that rearrangement of the MLL gene is involved in these translocations. The chromosomes most frequently involved in reciprocal translocations include chromosomes 4, 6, 9, and 19, and we and others have reported that chromosomes 1, 2, 10, 15, 17, 18, 22, and X are also involved. In the cell line Karpas 45, which has a t(X;11) (q13;q23) translocation, we report here that the MLL gene is rearranged and that there are two altered transcripts of MLL that come from the der(l I) chromosome. (C) 1994 Wiley-Liss, Inc.