EFFECT OF ADRENALECTOMY AND GLUCOCORTICOID TREATMENT ON THE LEVELS OF AN INSULIN-SENSITIVE GLYCOSYL-PHOSPHATIDYLINOSITOL IN ISOLATED RAT HEPATOCYTES

被引：9

作者：

CABELLO, MA

SANCHEZARIAS, JA

LIRAS, A

MATO, JM

FELIU, JE

机构：

[1] UNIV AUTONOMA MADRID,HOSP PUERTA HIERRO,SERV ENDOCRINOL EXPTL,SAN MARTIN PORRES 4,E-28035 MADRID,SPAIN

[2] CSIC,INST INVEST BIOMED,FDN JIMENEZ DIAZ,E-28040 MADRID,SPAIN

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 1990年 / 68卷 / 01期

关键词：

(Rat hepatocytes); Adrenalectomy; Glucocorticoid; Glycosyl-phosphatidylinositol; Insulin resistance;

D O I：

10.1016/0303-7207(90)90173-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Insulin resistance caused by dexamethasone administration to rats was accompanied by a marked decrease in the hepatocyte content of an insulin-sensitive glycosyl-phosphatidylinositol, as well as by a blockade of its hydrolysis in response to this hormone. In contrast, bilateral adrenalectomy provoked a significant increase of the cellular glycosyl-phosphatidylinositol levels. Under all the assayed metabolic conditions, a close direct correlation was established between the basal content of this compound and the number of insulin receptors present in the isolated hepatocytes. © 1990.

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页码：R1 / R5

页数：5

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